IL-13 as a novel growth factor in CTCL
نویسندگان
چکیده
منابع مشابه
IL-13 is a susceptibility factor for Leishmania major infection.
Leishmania major infection is useful as an experimental model to define factors responsible for the development and maintenance of Th cell immune responses. Studies using inbred mouse strains have identified that the Th1 response characteristic of C57BL/6 mice results in healing, whereas BALB/c mice fail to control the infection due to the generation of an inappropriate Th2 response. We now dem...
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antisense oligodeoxynucleotides (oligos) are the tools that bind to complemen¬tary sequence of targeted mrna and block specifically protein translation. in the present study, a novel 20 mer oligo as an antisense for human il-13 is introduced. this oligo is designed according to the il-13 mrna coding region and synthesized in two hplc purified and fitc conjugated forms. fluorescence oligo cell u...
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Introduction: Nutritional requirements of fungi are essential for their successful growth in laboratories. Some fungi feed on the compounds present in the insects' bodies. The aim of this study was to evaluate the effect of insects' body powder (IBP) as a supplement for the fungi growth in culture media. Methods: We used 10 mg of IBP, obtained from Anopheles superpictus and Culex theileri mosqu...
متن کاملIL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.
Hyperoxia is an important cause of acute lung injury. To determine whether IL-13 is protective in hyperoxia, we compared the survival in 100% O(2) of transgenic mice that overexpress IL-13 in the lung and of nontransgenic littermate controls. IL-13 enhanced survival in 100% O(2). One hundred percent of nontransgenic mice died in 4-5 days, whereas 100% of IL-13-overexpressing mice lived for more...
متن کاملIL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17
BACKGROUND The pleiotrophic cytokine interleukin (IL)-13 features prominently in allergic and inflammatory diseases. In allergic asthma, IL-13 is well established as an inducer of airway inflammation and tissue remodeling. We demonstrated previously that IL-13 induces release of transforming growth factor-alpha (TGFalpha) from human bronchial epithelial cells, with proliferation of these cells ...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-02-626432